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Jan 23, 2019 · Abstract. Silicosis is a common occupational disease and represents a significant contributor to respiratory morbidity and mortality worldwide. Lipid-laden macrophages, or foam cells, are observed ...Nov 14, 2023 · First, Hou et al. provide a molecular link between cholesterol metabolism and the cGAS-cGAMP-STING pathway. Although there are other negative regulators of cGAMP, the connection between SMPDL3A and LXR raises a myriad of intriguing questions. Does lipid and/or cholesterol metabolism stimulate DNA stress and cGAS activation, and if so, …

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